The board comes with a 5 phase voltage design. It has 2 PCI and 2 PCIe x16 (either 1 x PCIe x16 or 2 x PCIe x 8 for CrossFireX) and 2 PCIe x1 on board. Realtek and GbE and 8 ch audio codec are sighted on board.  Both north, south bridges are cooled passively with copper heatsink.

The board supports four 240-pin unbuffered non-ECC DDR II SDRAM DIMM sockets with up to 8GB of memory can be installed on board. For AM2 processors, DDR2-533/667/800 is supported. For Phenom AM2+, memory supported is DDR2-667/800/1066. It also support Asynchronous clocking mode between FSB and DIMM.

The new SB750 supports 12 USB connectors compliant with USB2.0 from embedded USB controller (4 connectors at rear panel). The iTE chip supports a P-ATA IDE for One IDE ports (up to 2 IDE devices) with UDMA-33, ATA-66/100/133 support The SB750 supports S-ATA RAID with Six S-ATA II ports with up to 300MB/s from chipset with RAID 0,1,0+1,5 support.

At the rear panel are PS/2 keyboard connector. There is a D-SUB, DVI and HDMI ports. Next to it is S/PDIF out followed by 4 USB, and 8 ch HDA audio ports.